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WMS 2020

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The peripapillary retinal nerve fiber layer in Leber’s hereditary optic neuropathy


Peripapillary retinal nerve fiber layer (pRNFL) thinning initially occurs in the temporal quadrant of the eye, followed by the inferior, superior and finally the nasal quadrants, continuing slowly in some cases for extended time periods.

Why this matters

  • There is a paucity of information on the changes in peripapillary pRNFL thickness in patients with chronic Leber’s hereditary optic neuropathy (LHON; mitochondrial condition causing acute/subacute visual loss) at different disease stages.
  • Greater knowledge of disease progression in LHON may be beneficial regarding development of management and therapeutic strategies for this rare disorder, with specific eye regions being targeted at different times.

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