Study points to new subtype of MS based on demyelination pattern


Specialists have identified a subtype of multiple sclerosis (MS) characterized by cortical neuronal loss independent of cerebral white-matter demyelination.

The details were presented in a “Hot Topic” session at ECTRIMS 2018 in Berlin, Germany.

Professor Bruce Trapp of the Lerner Research Institute at the Cleveland Clinic Foundation (Cleveland, Ohio, USA) noted that while demyelination of cerebral white matter is understood to drive neuronal degeneration in MS, recent imaging studies have suggested that demyelination and neuronal degeneration can occur independently.

To investigate further, sections from 97 postmortem MS brains were examined visually. A total of 12 were found to show no evidence of cerebral white-matter demyelination.

Ology Medical Education is a global provider of independent medical education. Its mission is to provide healthcare professionals with high-quality, trusted medical information with the aim of helping optimize patient care.

No responsibility is assumed by Ology Medical Education for any injury and/or damage to persons or property through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, Ology Medical Education recommends that independent verification of diagnoses and drug dosages should be made. The opinions expressed do not reflect those of Ology Medical Education or the sponsor. Ology Medical Education assumes no liability for any material contained herein.